Mariya A. Netes, Samson O. Afolabi, Andrei A. Lebedev, Eugenii R. Bychkov, Petr D. Shabanov
Ekaterina V. Skorb, and Sergey Shityakov
https://doi.org/10.1142/S2737416526500985
From the Abstract: This study looks at how stress and modern dietary environments may contribute to obesity and disordered eating, including compulsive overeating and food addiction. It focuses on ghrelin, a hormone that stimulates hunger, as a possible target for treatment.
Researchers tested two ghrelin-blocking compounds, D-Lys3-GHRP-6 and YIL 781, using computer modeling and experiments in stressed rats. The results showed that YIL 781 binds more strongly to the ghrelin receptor and reduces chocolate consumption in stressed rats, suggesting it may help reduce stress-related overeating.