About 10 percent of those who take Wegovy, Zepbound, etc. do not experience the results they seek, according to a New York Times article.
“Over 15 months on Zepbound, Ms. Layeux lost only a pound or two. ‘“’No matter what I do, these “miracle drugs”’” don’t work,’ she said.
“GLP-1 drugs like Zepbound have helped millions of people shed significant weight. But then there are the often-overlooked outliers: In clinical trials, about one in 10 people on the drugs were “non-responders,” losing less than 5 percent of their body weight, compared with the average of 15 to 21 percent. With so much attention on the benefits of these drugs, the experiences of non-responders are often overlooked.
“For these patients, it can be maddening to see no weight loss after months of treatment and thousands of dollars spent.”